Solvation of Model Biomolecules in Choline-Aminoate Ionic Liquids: A Computational Simulation Using Polarizable Force Fields

Solvation of Model Biomolecules in Choline-Aminoate Ionic Liquids: A Computational Simulation Using Polarizable Force Fields

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One can foresee a very near future where ionic liquids will be used in applications such as biomolecular chemistry or medicine.The molecular details of their interaction with biological matter, however, are difficult to investigate due to the vast number of combinations of both the biological systems and the variety of possible liquids.Here, Siemens LC87KBM60B IQ-300 Built In 79cm 3 Speeds B Chimney Cooker Hood Black we provide a computational study aimed at understanding the interaction of a special class of biocompatible Detent Pin ionic liquids (choline-aminoate) with two model biological systems: an oligopeptide and an oligonucleotide.

We employed molecular dynamics with a polarizable force field.Our results are in line with previous experimental and computational evidence on analogous systems and show how these biocompatible ionic liquids, in their pure form, act as gentle solvents for protein structures while simultaneously destabilizing DNA structure.